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Policy makers can formulate their decisions on smoking control priorities and resource allocation based on the magnitude of the effect and the consistency of the evidence relating smoking to each of the 36 outcomes, as represented by the ROS and star rating for each smokingoutcome association 187

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In contrast, human-derived spaces can express the overall Gestalt similarities that people see in drawings, potentially encompassing many factors beyond what neural networks currently capture: knowledge about parts, categories, functions, orientations, and so on, that can all jointly contribute to perceived similarity

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However, while valuable, this model had key limitations, including a lack of reproducible smoke dose delivery, the inability to assess cigarette smoke-induced toxicity in the distal lung, and the absence of essential readouts like trans-barrier electrical resistance (TER), restricting its applicability for studying alveolar-level injuries